FDA Km conversion · in vivo translation

Human Dosage Calculator

Translate an animal-study dose into a human equivalent dose using the body-surface-area method.

Simple calculator

Animal dose → human equivalent dose

Human K_m = 37

Input animal dose (mg/kg) Use the dose reported in the animal study.

Select animal type Values follow the FDA body-surface-area conversion table.

Human body weight (kg) Default: 60 kg adult human.

HED (mg/kg) = animal dose × animal K_m ÷ human K_m Human equivalent dose (mg) = HED × human body weight

Mouse HED 40.54 mg/kg

Human equivalent dose 2,432.43 mg for a 60 kg human

Based on the FDA body-surface-area method for deriving a human-equivalent dose from animal data.

Worked examples

Three real-world mushroom-study translations

These are mathematical translations of published animal-study doses, not recommended human doses.

Mouse · K_m 381.08 mg/kg HED

Ganoderma lucidum / G. sinense G2SO

Intervention: 1,000 mg/kg/day of a formulation containing G. lucidum spore oil plus fruiting-body extracts of G. lucidum and G. sinense; oral gavage for 21 days.

Model and observed effect: BALB/c mice with transplanted 4T1 mammary tumours. The study reported reduced tumour growth and a 35.31 ± 9.51% tumour-inhibition rate under the tested conditions.

= 4,864.86 mg for a 60 kg human equivalent

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Rat · K_m 617.59 mg/kg HED

Lion’s mane — Hericium erinaceus mycelium

Intervention: 108.5 mg/kg/day of wet mycelium administered orally on days 2–6 after injury.

Model and observed effect: Weight-drop mild traumatic brain-injury model in adult male Sprague–Dawley rats. The study reported mitigated motor deficits, preservation of neurons and reduced activated microglia in the brain.

= 1,055.68 mg for a 60 kg human equivalent

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Mouse · K_m 316.22 mg/kg HED

Shiitake — Lentinula edodes lentinan

Intervention: 200 mg/kg/day of water-extracted lentinan administered intragastrically for 10 days (days 6–15).

Model and observed effect: Cyclophosphamide-induced immunosuppression with intestinal-barrier injury in mice. The study reported mitigation of weight loss, immune-organ injury and cytokine abnormalities, alongside improved intestinal-barrier and microbiota measures.

= 972.97 mg for a 60 kg human equivalent

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Disclaimer — informational use only: This calculator applies the body-surface-area K_m conversion described in the U.S. Food and Drug Administration (FDA) Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers (July 2005). That FDA guidance contains nonbinding recommendations. This tool does not constitute medical, clinical, toxicological, regulatory, legal or pharmaceutical advice; it does not determine a safe, effective or lawful human dose; and it is not a recommendation to administer an intervention, begin a clinical trial or self-dose. No clinician–patient relationship is created. Users must obtain independent review from appropriately qualified medical, pharmacology/toxicology and regulatory professionals and are solely responsible for decisions based on any output. Sienet Solutions and Peter Petros provide this calculator without warranties and disclaim responsibility for loss, harm or claims arising from reliance on it, to the maximum extent permitted by law.